New TV documentary – Homelessness in London

Published on May 16, 2013 the number of London homelessness is rising 3 times faster than the rest of England. While the demand for help is up, the money is down. While eastern European account for a larger part of the homeless group. Nikola Ivanov is originally from Bulgaria and has been stuck in London for 8 months. via TV documentary--street voices - YouTube.

Bee Venom Can Kill HIV, Study Says

Source: usnews.com
Scientists from Washington University School of Medicine in St. Louis have discovered bee venom can kill the HIV virus without harming the body. Bees could hold the key to preventing HIV transmission. Researchers have discovered that bee venom kills the virus while leaving body cells unharmed, which could lead to an anti-HIV vaginal gel and other treatments. Scientists at the Washington University School of Medicine in St. Louis found that melittin, a toxin found in bee venom, physically destroys the HIV virus, a breakthrough that could potentially lead to drugs that are immune to HIV resistance. The study was published Thursday in the journal Antiviral Therapy. - See more at: http://www.whydontyoutrythis.com/2013/03/bee-venom-can-kill-hiv-study-says.html#sthash.wYa18nP3.0Xl9DGsU.dpuf
"Our hope is that in places where HIV is running rampant, people could use this as a preventative measure to stop the initial infection," Joshua Hood, one of the authors of the study, said in a statement. The researchers attached melittin to nanoparticles that are physically smaller than HIV, which is smaller than body cells. The toxin rips holes in the virus' outer layer, destroying it, but the particles aren't large enough to damage body cells. "Based on this finding, we propose that melittin-loaded nanoparticles are well-suited for use as topical vaginal HIV virucidal agents," they write. Theoretically, the particles could also be injected into an HIV-positive person to eliminate the virus in the bloodstream. Because the toxin attacks the virus' outer layer, the virus is likely unable to develop a resistance to the substance, which could make it more effective than other HIV drugs. "Theoretically, melittin nanoparticles are not susceptible to HIV mutational resistance seen with standard HIV therapies," they write. "By disintegrating the [virus'] lipid envelope [it's] less likely to develop resistance to the melittin nanoparticles." The group plans to soon test the gel in clinical trials. - See more at: http://www.whydontyoutrythis.com/2013/03/bee-venom-can-kill-hiv-study-says.html#sthash.wYa18nP3.0Xl9DGsU.dpuf

ITAR-TASS : Russian cosmonaut first earthling to pay taxes from space

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Sources indicate that Vinogradov’s rather unusual request was related to the Federal Tax Services by the first woman cosmonaut Valentina Tereshkova, who is currently a deputy of the State Duma.

The Federal Tax Service sent a codeword for the ‘member area’ Internet service that enables him to make payments anyplace he finds it possible to get connected to the worldwide web.

While staying aboard the ISS, Vinogradov managed to pay a tax for a plot of land he has in the Moscow region.

Mikhail Mishustin, the director of the Federal Taxation Service, confirmed the fact in a conversation with reporters on the sidelines of a Tax Administration Forum of the Organization for Economic Cooperation and Development, underway in Moscow now.

Pascal Saint-Amans, the director of the OECD Center for Tax Policy and Administration, said in this connection that the long arm of the Russian tax inspectors is already stretched as far out as the near-terrestrial space.

Russia is the only country today that has managed to raise taxes even from a person doing a tour of duty in space, Pascak said joikingly.

He added seriously that the countries dynamically introducing innovations in the field of tax administration are not many.

Love Is The Law

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E. coli is capable of producing a diesel substitute

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Strains of E. coli bacteria are capable of producing a biofuel almost identical to diesel.

The importance of the discovery hinges around the idea of "drop-in" fuels -- that existing technology which runs on diesel would not need to be modified in order to utilise the biofuel meaning the costs to business of switching energy sources would be minimal.

"Producing a commercial biofuel that can be used without needing to modify vehicles has been the goal of this project from the outset," said Professor John Love from the University of Exeter's Biosciences department.

"Replacing conventional diesel with a carbon neutral biofuel in commercial volumes would be a tremendous step towards meeting our target of an 80 percent reduction in greenhouse gas emissions by 2050. Global demand for energy is rising and a fuel that is independent of both global oil price fluctuations and political instability is an increasingly attractive prospect." The E. coli uses a natural oil production process to convert sugars into fats which are then used in the bacteria's cell membrane. By genetically altering the E. coli the researchers were able to convert the sugars to the imitation fossil fuel (perhaps faux-sil fuel?) instead. Unfortunately the process only yields tiny amounts of biodiesel at present meaning that before we can switch energy sources bioscientists will need to find a way to refine the process and produce industrial quantities of fuel.
The team at the University of Exeter received support for their project from multinational oil company, Shell. According to Rob Lee from Shell projects & technology: "While the technology still faces several hurdles to commercialisation, by exploring this new method of creating biofuel, along with other intelligent technologies, we hope they could help us to meet the challenges of limiting the rise in carbon dioxide emissions while responding to the growing global requirement for transport fuel."

Study: cannabis compound might have use as an HIV drug

SOURCE: http://www.wired.co.uk

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The chemical compound in cannabis, THC, appears to be able to damage and weaken the most common strain of the HIV virus.

Before you light up a spliff, though, this is only a preliminary result reached under laboratory conditions, and further research will be needed.

THC, or tetrahydrocannabinol, is the main psychoactive ingredient in cannabis -- it's the chemical that gets the user stoned. Synthetic versions of it have been developed for research purposes, and it's this that was used to attack the HIV-1 virus, which represents the vast majority (more than 90 percent) of all HIV types.

The way it works is by interaction with the cannabinoid type-2 (CB2) receptor in white blood cells, specifically the macrophages. Macrophages are one of many types of white blood cell in humans. While the main cells, the lymphocytes, do the bulk of the work in fighting infection by tracking down and destroying germs with antibodies, macrophages form a kind of backup part of the immune system -- attracted to damaged cells, they surround and engulf them while also alerting lymphocytes of new dangers. Macrophages have an unpleasant weakness, though, in that they are one of the first types of cells to be infected by HIV when it enters the body. The virus can live inside macrophages for days, weeks or months, travelling around the body, infecting other cells and acting as an extremely effective pollinator of HIV. Stopping the HIV virus from infecting macrophages is one method researchers are investigating, as it would dramatically curtail the speed at which the infection progresses and would give time for other antiretrovirals to help keep it at bay, or even remove it. The CB2 receptor in macrophages is stimulated normally when THC enters the bloodstream, so nothing unusual there. However, it appears that macrophages that have their CB2 receptor stimulated are stronger when it comes to fighting and weakening the HIV-1 virus. This was discovered when the research team from the Temple University School of Medicine in Philadelphia infected macrophages with the HIV-1 virus, before then exposing cell cultures to one of three types of synthetic THC that specifically target the CB2 receptor. Comparing these cell cultures after seven days against a control group revealed a clear decrease in the rate of HIV-1 infection. Effectively, the macrophages had become stronger at keeping the HIV-1 virus out. Pathologist Yuri Persidsky from Temple University, one of the study's authors, said: "The synthetic compounds we used in our study may show promise in helping the body fight HIV-1 infection. As compounds like these are improved further and made widely available, we will continue to explore their potential to fight other viral diseases that are notoriously difficult to treat." An added benefit of targeting only the CB2 receptor is that its only affect is to stimulate the macrophages -- the psychoactive component of THC is experienced when the CB1 receptor gets targeted. Synthetic THC compounds can be produced to only target the CB2 receptor in this way. THC has also been shown in studies not to suppress the immune systems of those who take it, meaning that the findings could provide hints at a future drug that, in combination with other methods, could be used for suppressing the HIV-1 virus.

The study has been published in The Journal of Leukocyte Biology.

Anti-cocaine vaccine eats up drug ‘like a little Pac-Man’

SOURCE: http://www.wired.co.uk/

cocaine

An anti-cocaine vaccine has been used successfully on non-human primates, bringing it one step closer to approval for use in human addiction therapy.

The vaccine (dAd5GNE) combines elements of the common cold virus with the particle GNE, which mimics cocaine. The vaccine works by preventing the dopamine high associated with taking cocaine.

"The vaccine eats up the cocaine in the blood like a little Pac-Man before it can reach the brain," said Ronald G Crystal, lead author of the study and chairman of the Department of Genetic Medicine at Weill Cornell Medical College.

"We believe this strategy is a win-win for those individuals, among the estimated 1.4 million cocaine users in the United States, who are committed to breaking their addiction to the drug. Even if a person who receives the anti-cocaine vaccine falls off the wagon, cocaine will have no effect." Cocaine works by binding to a dopamine transporter and blocking the recycling of dopamine in two areas of the brain (the putamen in the forebrain and the caudate nucleus, in case you were wondering) meaning those areas get flooded with dopamine and produce the drug high. The vaccine encourages the body to treat cocaine as an intruder and mount an immune response against the drug. According to the results of the study, non-human primates who had received the vaccine showed greatly reduced levels of cocaine binding to the dopamine transmitter. Less than 20 percent, in fact, which the study notes is "significantly below the 47 percent threshold required to evoke the subjective 'high' reported in humans". The results look promising but, if the vaccine is to help humans rather than coked up primates of different species, further studies will be required. One of the key questions non-human testing cannot help with is how effective the vaccine will actually be and how often it would need administering. "An anti-cocaine vaccination will require booster shots in humans, but we don't know yet how often these booster shots will be needed," said Crystal. "I believe that for those people who desperately want to break their addiction, a series of vaccinations will help."

To find out more about the research, don't miss this in-depth feature from our March issue, titled Addiction injection: the mission to immunise drug users against dependency.

2013-06-08 – First Anniversary of Portsmouth DIY Together Festival 2013 – THE BARN – PORTSMOUTH

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Who Is Trying To Patent Marijuana? – CSglobe

shutterstock The secret is out: marijuana is medicine. And not to the surprise of the pharmaceutical industry, who is slowly but surely gaining exclusive rights to the medical properties of this age-old plant. But wait. How can a company, other than Monsanto, patent a plant? That’s not a serious question, but it brings up a serious point. Patents on marijuana have yet to cover genetic modifications of the plant itself, but rather involve the cannabinoids found in marijuana that are responsible for its medical effects. Phytocannabinoids in the treatment of cancer (Patent No. US20130059018) The most recent patent filing on cannabinoids comes from none other than GW Pharmaceuticals – the UK-based company that manufactures Sativex (1). Sativex is an oral spray that contains cannabinoids derived from the cannabis plant itself, specifically THC and CBD. Although Sativex is not yet available in the U.S., it has already gained approval in Canada, the UK and eight other European countries. GW Pharma has been quick to recognize the market potential of cannabis and their most recent patent application makes this more than clear. Just from the title of the patent, one gets a good sense of what GW Pharma has been trying to claim as their own. “Phytocannabinoids” simply means cannabinoids derived from plants, referring to the cannabis plant in this case. Unsurprisingly, it appears as though GW Pharma encountered difficulties in trying to claim such a broad “invention”. In fact, the updated version of their patent application shows that more than half of their original patent claims were retracted, and for good reason too. Looking back in time, GW Pharma made claims to just the use of isolated cannabinoids in the treatment of cancer, which is no more of an invention than it is a theft from individuals who first proclaimed marijuana’s cancer-fighting abilities decades ago. On the other hand, GW Pharma’s remaining claims might just pass through the Patent Office without further questioning. GW Pharma seems to be familiar with the pharmaceutical industry’s shrewd patent strategies, which involves modifying pre-existing compounds that have already been proven to work. In this case, all GW Pharma had to do was claim that they invented a cannabis-based botanical drug substance for treating cancer – botanical drug substance meaning any form of marijuana prepared by methods as simple as aqueous or ethanolic extraction. There you have it. GW Pharma invented neither cannabis nor a method of extraction, but still consider themselves to be inventors of “phytocannabinoids in the treatment of cancer”. Cannabinoids as antioxidants and neuroprotectants (Patent No. US6630507) Perhaps the most infamous marijuana-related patent belongs to the U.S. federal government themselves. Indeed, while federal agents have been keeping busy trying to defend their stance on pot prohibition, they also made sure to file patents on the medical components of the very same Schedule I drug. The funny thing is, this particular patent dates all the way back to 1998 when Bill “didn’t inhale” Clinton was still president. Although federal patent writers made sure to include a long list of synthetic cannabinoids within their claims, carefully tucked away is none other than cannabidiol, also known as CBD. Once again, the inventive step in this patent seems to be severely lacking, but maybe the federal government gets more flexibility with their patent filings. Regardless, it seems as though the use of CBD for the treatment of “stroke and trauma”, “Alzheimer’s disease, Parkinson’s disease and HIV dementia” and a “wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases” all belongs to the White House, at least for the next 10 years until their patent expires. Private funding matters more It might be easy to blame an outdated patent system for what seems to be just another one of the many injustices that plague the private health care system. But the truth is, it’s not really the Patent Office’s fault that marijuana is being taken over by capital-backed corporations and government agencies. Rather, the fault lies in the restrictive nature of medical marijuana research, which is overseen by the National Institute on Drug Abuse (NIDA) – the only source of legal marijuana in the U.S. According to researchers (2) who have attempted to conduct clinical trials on cannabis, the NIDA is simply uninterested in supplying cannabis for medical studies, in accordance with a mandate from Congress that limits NIDA researchers to investigating the marijuana’s dangers. And being the overwhelmingly benign substance (3) that it is, marijuana hasn’t been the subject of many NIDA studies for a while now. But perhaps the worst outcome of this situation is not the fact that clinical research on medical marijuana is severely lacking. No, the worst part is that the gap in research is eagerly being filled by corporations like GW Pharma. Indeed, while there were a total 37 clinical studies (4) conducted on cannabinoids between 2005-2009, only 8 of them involved actual marijuana. On the other hand, 9 of the 37 studies involved Sativex, with the rest consisting of a variety of synthetic THC formulations, no doubt sponsored by their respective manufacturers as well. So where does this leave the rest of us? Not too far from where we started off it seems, since it’s no surprise to anyone that healthcare will continue to be driven by privately funded research, even in the case of marijuana. But all that research money has to come from somewhere, and you can bet it’s not coming from the deep pockets of GW Pharma’s executive board. As it turns out, a couple of shrewd businessmen with knowledge of medicine realized long ago that sick and dying individuals will pay almost any price for the promise of relief, even if it happens to be all of their life savings and then some. What happened to these businessmen? Oh, they’re still around. We just call them Big Pharma.

ANGIE BOWIE

Good Morning! How are you? I am off to the studio again today. We will be releasing FANCY FOOTWORK the new album in the next few week but we will release Amina's Waltz next week! 601682_10151320579226599_791659987_n