FACEBOOK INVITE FOR EVENT :

ITAR-TASS : Russian cosmonaut first earthling to pay taxes from space

Published Friday 17th May, 2013

Sources indicate that Vinogradov’s rather unusual request was related to the Federal Tax Services by the first woman cosmonaut Valentina Tereshkova, who is currently a deputy of the State Duma.

The Federal Tax Service sent a codeword for the ‘member area’ Internet service that enables him to make payments anyplace he finds it possible to get connected to the worldwide web.

While staying aboard the ISS, Vinogradov managed to pay a tax for a plot of land he has in the Moscow region.

Mikhail Mishustin, the director of the Federal Taxation Service, confirmed the fact in a conversation with reporters on the sidelines of a Tax Administration Forum of the Organization for Economic Cooperation and Development, underway in Moscow now.

Pascal Saint-Amans, the director of the OECD Center for Tax Policy and Administration, said in this connection that the long arm of the Russian tax inspectors is already stretched as far out as the near-terrestrial space.

Russia is the only country today that has managed to raise taxes even from a person doing a tour of duty in space, Pascak said joikingly.

He added seriously that the countries dynamically introducing innovations in the field of tax administration are not many.

Study: cannabis compound might have use as an HIV drug

Published Friday 17th May, 2013

SOURCE: http://www.wired.co.uk

The chemical compound in cannabis, THC, appears to be able to damage and weaken the most common strain of the HIV virus.

Before you light up a spliff, though, this is only a preliminary result reached under laboratory conditions, and further research will be needed.

THC, or tetrahydrocannabinol, is the main psychoactive ingredient in cannabis -- it's the chemical that gets the user stoned. Synthetic versions of it have been developed for research purposes, and it's this that was used to attack the HIV-1 virus, which represents the vast majority (more than 90 percent) of all HIV types.

The way it works is by interaction with the cannabinoid type-2 (CB2) receptor in white blood cells, specifically the macrophages. Macrophages are one of many types of white blood cell in humans. While the main cells, the lymphocytes, do the bulk of the work in fighting infection by tracking down and destroying germs with antibodies, macrophages form a kind of backup part of the immune system -- attracted to damaged cells, they surround and engulf them while also alerting lymphocytes of new dangers. Macrophages have an unpleasant weakness, though, in that they are one of the first types of cells to be infected by HIV when it enters the body. The virus can live inside macrophages for days, weeks or months, travelling around the body, infecting other cells and acting as an extremely effective pollinator of HIV. Stopping the HIV virus from infecting macrophages is one method researchers are investigating, as it would dramatically curtail the speed at which the infection progresses and would give time for other antiretrovirals to help keep it at bay, or even remove it. The CB2 receptor in macrophages is stimulated normally when THC enters the bloodstream, so nothing unusual there. However, it appears that macrophages that have their CB2 receptor stimulated are stronger when it comes to fighting and weakening the HIV-1 virus. This was discovered when the research team from the Temple University School of Medicine in Philadelphia infected macrophages with the HIV-1 virus, before then exposing cell cultures to one of three types of synthetic THC that specifically target the CB2 receptor. Comparing these cell cultures after seven days against a control group revealed a clear decrease in the rate of HIV-1 infection. Effectively, the macrophages had become stronger at keeping the HIV-1 virus out. Pathologist Yuri Persidsky from Temple University, one of the study's authors, said: "The synthetic compounds we used in our study may show promise in helping the body fight HIV-1 infection. As compounds like these are improved further and made widely available, we will continue to explore their potential to fight other viral diseases that are notoriously difficult to treat." An added benefit of targeting only the CB2 receptor is that its only affect is to stimulate the macrophages -- the psychoactive component of THC is experienced when the CB1 receptor gets targeted. Synthetic THC compounds can be produced to only target the CB2 receptor in this way. THC has also been shown in studies not to suppress the immune systems of those who take it, meaning that the findings could provide hints at a future drug that, in combination with other methods, could be used for suppressing the HIV-1 virus.

The study has been published in The Journal of Leukocyte Biology.

Who Is Trying To Patent Marijuana? – CSglobe

Published Monday 13th May, 2013 The secret is out: marijuana is medicine. And not to the surprise of the pharmaceutical industry, who is slowly but surely gaining exclusive rights to the medical properties of this age-old plant. But wait. How can a company, other than Monsanto, patent a plant? That’s not a serious question, but it brings up a serious point. Patents on marijuana have yet to cover genetic modifications of the plant itself, but rather involve the cannabinoids found in marijuana that are responsible for its medical effects. Phytocannabinoids in the treatment of cancer (Patent No. US20130059018) The most recent patent filing on cannabinoids comes from none other than GW Pharmaceuticals – the UK-based company that manufactures Sativex (1). Sativex is an oral spray that contains cannabinoids derived from the cannabis plant itself, specifically THC and CBD. Although Sativex is not yet available in the U.S., it has already gained approval in Canada, the UK and eight other European countries. GW Pharma has been quick to recognize the market potential of cannabis and their most recent patent application makes this more than clear. Just from the title of the patent, one gets a good sense of what GW Pharma has been trying to claim as their own. “Phytocannabinoids” simply means cannabinoids derived from plants, referring to the cannabis plant in this case. Unsurprisingly, it appears as though GW Pharma encountered difficulties in trying to claim such a broad “invention”. In fact, the updated version of their patent application shows that more than half of their original patent claims were retracted, and for good reason too. Looking back in time, GW Pharma made claims to just the use of isolated cannabinoids in the treatment of cancer, which is no more of an invention than it is a theft from individuals who first proclaimed marijuana’s cancer-fighting abilities decades ago. On the other hand, GW Pharma’s remaining claims might just pass through the Patent Office without further questioning. GW Pharma seems to be familiar with the pharmaceutical industry’s shrewd patent strategies, which involves modifying pre-existing compounds that have already been proven to work. In this case, all GW Pharma had to do was claim that they invented a cannabis-based botanical drug substance for treating cancer – botanical drug substance meaning any form of marijuana prepared by methods as simple as aqueous or ethanolic extraction. There you have it. GW Pharma invented neither cannabis nor a method of extraction, but still consider themselves to be inventors of “phytocannabinoids in the treatment of cancer”. Cannabinoids as antioxidants and neuroprotectants (Patent No. US6630507) Perhaps the most infamous marijuana-related patent belongs to the U.S. federal government themselves. Indeed, while federal agents have been keeping busy trying to defend their stance on pot prohibition, they also made sure to file patents on the medical components of the very same Schedule I drug. The funny thing is, this particular patent dates all the way back to 1998 when Bill “didn’t inhale” Clinton was still president. Although federal patent writers made sure to include a long list of synthetic cannabinoids within their claims, carefully tucked away is none other than cannabidiol, also known as CBD. Once again, the inventive step in this patent seems to be severely lacking, but maybe the federal government gets more flexibility with their patent filings. Regardless, it seems as though the use of CBD for the treatment of “stroke and trauma”, “Alzheimer’s disease, Parkinson’s disease and HIV dementia” and a “wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases” all belongs to the White House, at least for the next 10 years until their patent expires. Private funding matters more It might be easy to blame an outdated patent system for what seems to be just another one of the many injustices that plague the private health care system. But the truth is, it’s not really the Patent Office’s fault that marijuana is being taken over by capital-backed corporations and government agencies. Rather, the fault lies in the restrictive nature of medical marijuana research, which is overseen by the National Institute on Drug Abuse (NIDA) – the only source of legal marijuana in the U.S. According to researchers (2) who have attempted to conduct clinical trials on cannabis, the NIDA is simply uninterested in supplying cannabis for medical studies, in accordance with a mandate from Congress that limits NIDA researchers to investigating the marijuana’s dangers. And being the overwhelmingly benign substance (3) that it is, marijuana hasn’t been the subject of many NIDA studies for a while now. But perhaps the worst outcome of this situation is not the fact that clinical research on medical marijuana is severely lacking. No, the worst part is that the gap in research is eagerly being filled by corporations like GW Pharma. Indeed, while there were a total 37 clinical studies (4) conducted on cannabinoids between 2005-2009, only 8 of them involved actual marijuana. On the other hand, 9 of the 37 studies involved Sativex, with the rest consisting of a variety of synthetic THC formulations, no doubt sponsored by their respective manufacturers as well. So where does this leave the rest of us? Not too far from where we started off it seems, since it’s no surprise to anyone that healthcare will continue to be driven by privately funded research, even in the case of marijuana. But all that research money has to come from somewhere, and you can bet it’s not coming from the deep pockets of GW Pharma’s executive board. As it turns out, a couple of shrewd businessmen with knowledge of medicine realized long ago that sick and dying individuals will pay almost any price for the promise of relief, even if it happens to be all of their life savings and then some. What happened to these businessmen? Oh, they’re still around. We just call them Big Pharma.

ANGIE BOWIE

Published Thursday 09th May, 2013 Good Morning! How are you? I am off to the studio again today. We will be releasing FANCY FOOTWORK the new album in the next few week but we will release Amina's Waltz next week!